Plinest Polynucleotides is an advanced injectable skin regeneration treatment designed to improve skin quality at a cellular level. It works by stimulating the skin’s natural repair processes, helping to restore elasticity, hydration and overall skin health.
Unlike dermal fillers, Plinest does not add volume or change facial structure. Instead, it supports true skin regeneration, improving the quality, thickness and resilience of the skin over time.
At our clinic, Plinest is used as part of a regenerative approach to skin ageing, particularly for delicate areas such as the under-eyes, as well as the face and neck.
What Are Polynucleotides?
Polynucleotides are biologically derived molecules that support skin repair and regeneration. Plinest is a purified injectable formulation that works by stimulating fibroblasts — the cells responsible for producing collagen, elastin and healthy skin tissue.
Unlike treatments that simply hydrate or fill, polynucleotides actively encourage the skin to repair itself from within.
This makes them particularly effective for patients with:
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Thin or ageing skin
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Under-eye hollowness or crepiness (skin quality related)
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Sun-damaged skin
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Acne scarring or textural irregularities
What are the Benefits of Polynucleotides?
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Stimulates natural skin regeneration and repair
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Improves skin elasticity and firmness
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Enhances hydration and skin texture
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Reduces appearance of fine lines and crepey skin
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Improves under-eye skin quality
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Supports healing of damaged or ageing skin
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Helps improve acne scarring and skin dullness
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Strengthens thin or weakened skin
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Non-volumising and natural-looking
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Suitable for face, neck and under-eye areas
How Do Polynucleotides Work?
Plinest works through a regenerative biological process:
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Stimulates fibroblast activity in the skin
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Enhances tissue repair and regeneration
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Improves microcirculation and skin oxygenation
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Strengthens the dermal structure over time
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Increases hydration retention and elasticity
The result is healthier, stronger and more resilient skin that improves gradually over time.
Treatment Areas
Plinest can be used across multiple areas of the face and body:
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Under-Eye Area
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Crepey skin
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Fine lines
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Thin or tired-looking skin
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Skin quality-related dark circles
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Face
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Dull or tired skin
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Fine lines and early ageing
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Acne scarring
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Uneven texture
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Neck
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Crepey or ageing skin
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Loss of elasticity
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Horizontal lines
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Décolletage
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Sun damage
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Skin thinning
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Texture irregularities
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Polynucleotides for Under-Eye Rejuvenation
One of the most popular uses for Plinest is the under-eye area.
It can help improve:
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Thin, crepey under-eye skin
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Fine lines and texture changes
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Tired or aged appearance
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Skin quality-related dark circles
Because it does not add volume, Plinest is often an ideal alternative or complement to tear trough filler in patients where skin quality is the primary concern.
CONSULTATION
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A full consultation is required before treatment.
We will:
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Assess your skin quality and concerns
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Determine suitability for polynucleotide treatment
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Discuss whether Plinest alone or combined treatment is best
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Review medical history and contraindications
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Explain expected results and treatment course
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Create a personalised regenerative skin plan
As this is a prescription-based injectable treatment, clinical assessment is required before treatment.
TREATMENT
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Plinest is delivered via small, precise injections into the targeted skin layers.
Your appointment includes:
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Skin assessment and treatment planning
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Cleansing and preparation of the treatment area
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Micro-injections of Plinest into targeted zones
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Aftercare guidance
A topical numbing cream may be used, especially for under-eye treatments.
Treatment typically takes 20–30 minutes.
AFTERCARE
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Following treatment, we recommend:
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Avoid touching or rubbing treated areas for 24 hours
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Avoid strenuous exercise for 24 hours
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Avoid alcohol on the day of treatment where possible
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Avoid excessive heat (saunas/steam rooms) for 24–48 hours
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Avoid makeup on treated areas for at least 12 hours if possible
Mild swelling, redness or small bumps may occur and typically resolve within 24–48 hours.
Our Approach to Skin Regeneration
We take a full-face regenerative approach rather than treating isolated concerns.
Before treatment, we assess:
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Skin thickness and elasticity
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Degree of sun damage or ageing
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Under-eye quality and structural support needs
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Presence of scarring or textural issues
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Overall facial ageing pattern
Plinest often works best as part of a combined skin plan, which may include:
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Sunekos (amino acid-based regeneration)
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Profhilo (hydration and bio-remodelling)
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Microneedling or RF treatments
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Botox (expression line control)
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Dermal fillers (structural support where needed)
Are Polynucleotides Right For You?
This treatment may be suitable if you:
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Have thin or ageing skin
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Notice crepey texture under the eyes or on the face
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Want improved skin quality without filler
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Have acne scarring or uneven texture
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Are seeking regenerative, long-term skin improvement
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Prefer natural, non-volumising treatments
Treatment may not be suitable if you:
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Are pregnant or breastfeeding
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Have active skin infection or inflammation
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Are unsuitable following clinical assessment
Why Choose Our Clinic?
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Advanced regenerative skin treatment expertise
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Full under-eye and facial skin assessment
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Experience with polynucleotide therapies
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Natural, non-volumising approach
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Combination treatment planning expertise
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High medical standards and safety focus
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Comprehensive aftercare and support
Medical Led | Registered | Fully Insured
Wanting deeply restored, radiant, and healthier-looking skin?
If you are concerned about thinning skin, crepey texture or tired-looking under-eyes, Plinest polynucleotides can help restore skin quality from within.
Book your consultation today for a personalised regenerative skin assessment and treatment plan tailored to your needs.
We welcome clients from Rainworth, Mansfield, Blidworth, Ravenshead, Farnsfield and other surrounding Nottinghamshire areas.